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Am J Primatol. 2019 Aug;81(8):e23028. doi: 10.1002/ajp.23028. Epub 2019 Jul 18.

AVPR1b variation and the emergence of adaptive phenotypes in Platyrrhini primates.

Author information

1
Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
2
INAGEMP - Instituto de Genética Médica e Populacional, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
3
Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
4
Departamento de Bioquímica e Imunologia, Faculdade de Medicina, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
5
Centro de Primatologia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
6
Departamento de Biologia Geral, Instituto de Biologia, Universidade Federal da Bahia, Salvador, Brazil.

Abstract

Platyrrhini (New World monkeys, NWm) are a group of primates characterized by behavioral and reproductive traits that are otherwise uncommon among primates, including social monogamy, direct paternal care, and twin births. As a consequence, the study of Platyrrhine primates is an invaluable tool for the discovery of the genetic repertoire underlying these taxon-specific traits. Recently, high conservation of vasopressin (AVP) sequence, in contrast with high variability of oxytocin (OXT), has been described in NWm. AVP and OXT functions are possible due to interaction with their receptors: AVPR1a, AVPR1b, AVPR2, and OXTR; and the variability in this system is associated with the traits mentioned above. Understanding the variability in the receptors is thus fundamental to understand the function and evolution of the system as a whole. Here we describe the variability of AVPR1b coding region in 20 NWm species, which is well-known to influence behavioral traits such as aggression, anxiety, and stress control in placental mammals. Our results indicate that 4% of AVPR1b sites may be under positive selection and a significant number of sites under relaxed selective constraint. Considering the known role of AVPR1b, we suggest that some of the changes described here for the Platyrrhini may be a part of the genetic repertoire connected with the complex network of neuroendocrine mechanisms of AVP-OXT system in the modulation of the HPA axis. Thus, these changes may have promoted the emergence of social behaviors such as direct paternal care in socially monogamous species that are also characterized by small body size and twin births.

KEYWORDS:

New World monkeys; molecular evolution; reproductive traits; social behavior

PMID:
31318063
DOI:
10.1002/ajp.23028

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