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Mult Scler. 2019 Jul 18:1352458519863644. doi: 10.1177/1352458519863644. [Epub ahead of print]

A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?

Author information

1
Department of Anatomy & Neurosciences, MS Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
2
REVAL Rehabilitation Research Center, BIOMED, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium; Institute of Psychoacoustics and Electronic Music (IPEM), Faculty of Arts and Philosophy, Gent University, Gent, Belgium.
3
Fit up Physiotherapy Center, Kontich, Belgium.
4
REVAL Rehabilitation Research Center, BIOMED, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium; Rehabilitation and MS Centre Overpelt, Overpelt, Belgium.
5
REVAL Rehabilitation Research Center, BIOMED, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium.

Abstract

BACKGROUND/OBJECTIVE:

Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS.

METHODS/RESULTS:

Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only.

CONCLUSION:

As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.

KEYWORDS:

Multiple sclerosis; cognitive rehabilitation; default-mode network; endurance exercise; functional connectivity; hippocampus

PMID:
31317828
DOI:
10.1177/1352458519863644

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