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Pediatr Cardiol. 2019 Aug;40(6):1284-1288. doi: 10.1007/s00246-019-02149-5. Epub 2019 Jul 18.

Ivabradine in Post-operative Junctional Ectopic Tachycardia (JET): Breaking New Ground.

Author information

1
Department of Pediatric Cardiology, Amrita Institute of Medical Sciences, AIMS Ponekkara (P.O), Kochi, 682041, India. mann_comp@hotmail.com.
2
Department of Pediatric Cardiology, Amrita Institute of Medical Sciences, AIMS Ponekkara (P.O), Kochi, 682041, India.
3
Department of Pediatrics (Cardiology), Oregon Health & Science University, Portland, OR, USA.

Abstract

Junctional ectopic tachycardia (JET) is the commonest tachyarrhythmia in the early post-operative period in children undergoing open-heart surgery. It frequently leads to hemodynamic instability and needs to be managed aggressively. Amiodarone is the first-line agent along with non-pharmacological interventions. We report our initial experience with the use of Ivabradine in post-operative JET. A retrospective case records review of children with post-operative JET during the period from June 2018 to May 2019 was performed. Eight patients with post-operative JET were treated with Ivabradine during this period. The first patient was initially treated with Amiodarone. All eight patients responded to Ivabradine. The initial response was rate control permitting overdrive pacing. One patient had recurrence of JET 10 h after Ivabradine and after return to sinus rhythm. Amiodarone was administered along with the second dose of Ivabradine resulting in remission to sinus rhythm. Ivabradine appears to be an effective alternative to Amiodarone in children with post-operative JET based on our initial clinical experience.

KEYWORDS:

Anti-arrhythmic therapy; Funny current channel (I f); Post-operative arrhythmias

PMID:
31317219
DOI:
10.1007/s00246-019-02149-5
[Indexed for MEDLINE]

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