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J Pediatr Neurosci. 2019 Jan-Mar;14(1):16-19. doi: 10.4103/jpn.JPN_20_19.

Molecular Basis of Spina Bifida: Recent Advances and Future Prospectives.

Author information

1
Department of Paediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
2
Department of Radiology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
3
Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
4
Department of Paediatric Surgery, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

Abstract

Background:

Spina bifida (SB) (spinal neural tube [NT] defects) is basically caused by an abnormality at the closure of the NT.

Materials and Methods:

Molecular researchers have now got new etiopathogenesis of the defective neural tube closure. Although molecular mechanisms in the SB is really important taxation for further work. We understand through the unique novel mutant responsible genes and modifying genes and included the different molecular aspects of SB from the available tools and databases and excluded the case reports.

Statistical Analysis:

We use here simple statistics (percentage, mean, median, and average) through the Statistical Package for the Social Sciences (SPSS), version 14, and found P > 0.0001 to be significant.

Results:

We have reported that the majority of 90% genes are responsible in SB and their associated diseases. These innovative unique patterns of responsible genes attached with the result abnormalities at the neuronal and non neuronal tissues are equally important for the SB and NTC.

Conclusion:

Our present ideology is aiming to understand the inductive and direct interactions of the downstream target sites among responsible regulating genes (RRGs). It is an unique pattern of genetic roadmap to control and guides the neurulation and may provide further insights into the causes of SB and may help to develop new molecular-targeted therapy (MTT).

KEYWORDS:

New tools; genes; genome-wide association study; molecular-targeted therapy; neural tube closure; spina bifida

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