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Nature. 2019 Aug;572(7767):56-61. doi: 10.1038/s41586-019-1407-9. Epub 2019 Jul 17.

Incompatible and sterile insect techniques combined eliminate mosquitoes.

Author information

1
Key Laboratory of Tropical Disease Control of the Ministry of Education, Sun Yat-sen University-Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
2
Insect Pest Control Laboratory, Joint FAO/IAEA Programme of Nuclear Techniques in Food and Agriculture, Vienna International Centre, Vienna, Austria.
3
Guangzhou Wolbaki Biotech Co., Ltd, Guangzhou, China.
4
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA.
5
School of Medicine, Hunan Normal University, Changsha, China.
6
Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
7
Department of Mathematics, Michigan State University, East Lansing, MI, USA.
8
Center for Applied Mathematics, College of Mathematics and Information Sciences, Guangzhou University, Guangzhou, China.
9
Department of Entomology, Nanjing Agricultural University, Nanjing, China.
10
Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
11
State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
12
Lingnan Statistical Science Research Institute, Guangzhou University, Guangzhou, China.
13
Bio21 Institute, School of BioSciences, University of Melbourne, Melbourne, Victoria, Australia.
14
Key Laboratory of Tropical Disease Control of the Ministry of Education, Sun Yat-sen University-Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. xizy@msu.edu.
15
Guangzhou Wolbaki Biotech Co., Ltd, Guangzhou, China. xizy@msu.edu.
16
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA. xizy@msu.edu.

Abstract

The radiation-based sterile insect technique (SIT) has successfully suppressed field populations of several insect pest species, but its effect on mosquito vector control has been limited. The related incompatible insect technique (IIT)-which uses sterilization caused by the maternally inherited endosymbiotic bacteria Wolbachia-is a promising alternative, but can be undermined by accidental release of females infected with the same Wolbachia strain as the released males. Here we show that combining incompatible and sterile insect techniques (IIT-SIT) enables near elimination of field populations of the world's most invasive mosquito species, Aedes albopictus. Millions of factory-reared adult males with an artificial triple-Wolbachia infection were released, with prior pupal irradiation of the released mosquitoes to prevent unintentionally released triply infected females from successfully reproducing in the field. This successful field trial demonstrates the feasibility of area-wide application of combined IIT-SIT for mosquito vector control.

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PMID:
31316207
DOI:
10.1038/s41586-019-1407-9
[Indexed for MEDLINE]

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