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J Clin Microbiol. 2019 Jul 17. pii: JCM.01129-19. doi: 10.1128/JCM.01129-19. [Epub ahead of print]

Point-Counterpoint: Differences between the European Committee on Antimicrobial Susceptibility Testing and the Clinical Laboratory Standards Institute Recommendations for Reporting Antimicrobial Susceptibility Results.

Author information

1
EUCAST Steering Committee; Clinical microbiology, Central hospital, Växjö, Sweden.
2
EUCAST Steering Committee; Clinical microbiology, Central hospital, Växjö, Sweden christian.giske@eucast.org kirntj@rwjms.rutgers.edu.
3
Clinical microbiology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
4
Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA christian.giske@eucast.org kirntj@rwjms.rutgers.edu.
5
Copan Diagnostics, Inc., Murrieta, CA, USA.

Abstract

Antibiotic susceptibility test results are among the most important results issued by clinical microbiology laboratories because they routinely guide critical treatment decisions. Interpretations of minimum inhibitory concentration or disk diffusion test results such as "susceptible" or "resistant" are easily understood. Clinical laboratories also need to determine whether and how their reports will reflect more complex situations. Such situations include, first, the need to administer higher or more frequent doses of antibiotic than usual for clinical efficacy, second, that an antimicrobial is likely to be effective at a body site where it concentrates and, third, that there is some uncertainty in the test results due to technical variability that cannot be eliminated. Two leading organizations that set standards for antimicrobial susceptibility testing, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) and the Clinical Laboratory Standards Institute (CLSI), have taken different strategies to deal with these challenges. In this Point-Counterpoint, Gunnar Kahlmeter and Christian Giske discuss how EUCAST is addressing these issues, and Thomas Kirn and Susan Sharp discuss the CLSI approach.

PMID:
31315957
DOI:
10.1128/JCM.01129-19

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