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Leuk Res. 1988;12(4):345-55.

Establishment of an immature mast cell line from a patient with mast cell leukemia.

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Department of Internal Medicine (Division of Allergic Diseases), Mayo Clinic, Rochester, MN 55905.


A cell line showing many characteristics of immature mast cells has been established from the peripheral blood of a patient with mast cell leukemia. Cultured cells contain low levels of histamine, are stained metachromatically by toluidine blue, and contain chloroacetate esterase, aminocaproate esterase and tryptase activities. The cells lack T and B lymphocyte, as well as myeloid cell markers, and do not possess IgE receptors. Solid tumors of metachromatically positive cells have been successfully induced and serially passed in nude mice using 5-azacytidine transformed cells. This cell line may be useful for future studies of mast cells and their constituents.

[Indexed for MEDLINE]

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