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Nutrients. 2019 Jul 16;11(7). pii: E1609. doi: 10.3390/nu11071609.

Maternal Selenium, Copper and Zinc Concentrations in Early Pregnancy, and the Association with Fertility.

Author information

1
Robinson Research Institute, University of Adelaide, 5005 North Adelaide, South Australia, Australia. jessica.grieger@adelaide.edu.au.
2
Adelaide Medical School, University of Adelaide, 5005 Adelaide, South Australia, Australia. jessica.grieger@adelaide.edu.au.
3
Robinson Research Institute, University of Adelaide, 5005 North Adelaide, South Australia, Australia.
4
Adelaide Medical School, University of Adelaide, 5005 Adelaide, South Australia, Australia.
5
Current affiliation: Center for Fetal and Placental Research, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH 45229, USA.
6
Waite Research Institute, School of Agriculture, Food and Wine, University of Adelaide, 5064 Adelaide, South Australia, Australia.
7
School of Medical Science, Griffith University, Gold Coast Campus, 4215 Southport, Queensland, Australia.
8
Fertility SA, 5000 Adelaide, South Australia, Australia.
9
Women and Children's Division, Lyell McEwin Hospital, University of Adelaide, 5112 Adelaide, South Australia, Australia.

Abstract

Trace elements such as zinc, copper, and selenium are essential for reproductive health, but there is limited work examining how circulating trace elements may associate with fertility in humans. The aim of this study was to determine the association between maternal plasma concentrations of zinc, copper, and selenium, and time to pregnancy and subfertility. Australian women (n = 1060) who participated in the multi-centre prospective Screening for Pregnancy Endpoints study were included. Maternal plasma concentrations of copper, zinc and selenium were assessed at 15 ± 1 weeks' gestation. Estimates of retrospectively reported time to pregnancy were documented as number of months to conceive; subfertility was defined as taking more than 12 months to conceive. A range of maternal and paternal adjustments were included. Women who had lower zinc (time ratio, 1.20 (0.99-1.44)) or who had lower selenium concentrations (1.19 (1.01-1.40)) had a longer time to pregnancy, equivalent to a median difference in time to pregnancy of around 0.6 months. Women with low selenium concentrations were also at a 1.46 (1.06-2.03) greater relative risk for subfertility compared to women with higher selenium concentrations. There were no associations between copper and time to pregnancy or subfertility. Lower selenium and zinc trace element concentrations, which likely reflect lower dietary intakes, associate with a longer time to pregnancy. Further research supporting our work is required, which may inform recommendations to increase maternal trace element intake in women planning a pregnancy.

KEYWORDS:

copper; fertility; pregnancy; selenium; subfertility; time to pregnancy; trace elements; zinc

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