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Am J Med Genet A. 2019 Sep;179(9):1820-1825. doi: 10.1002/ajmg.a.61292. Epub 2019 Jul 16.

Dental abnormalities in individuals with pathogenic germline variation in DICER1.

Author information

1
Office of the Clinical Director, National Institute of Dental and Craniofacial Research, Bethesda, Maryland.
2
Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
3
BioMedical Computer Research Institute, Philadelphia, Pennsylvania.
4
Westat, Inc, Rockville, Maryland.
5
International Pleuropulmonary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, Minnesota.
6
International Ovarian and Testicular Stromal Tumor Registry, Children's Minnesota, Minneapolis, Minnesota.
7
Cancer and Blood Disorders, Children's Minnesota, Minneapolis, Minnesota.
8
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH Rockville, Maryland.

Abstract

Pathogenic germline variation in the microRNA processing gene DICER1 gives rise to an autosomal dominant, tumor-predisposition disorder. Conditional deletion of Dicer1 in murine dental epithelium shows that it controls tooth patterning, size, number, and shape. The human dental phenotype of people with germline pathogenic variation in DICER1 is unknown. DICER1-carriers (n = 57) and family controls (n = 55) were evaluated at the NIH Clinical Center dental clinic as part of a comprehensive medical evaluation. Digital panoramic radiographs, bite-wing radiographs, and oral photographs were collected. A single observer, blind to DICER1 status, reviewed the dental records and determined the presence or absence of 11 dental characteristics as described in the clinic notes, radiographs, or oral photographs. Subjective phenotypes were reviewed on radiographs by two examiners (blind to DICER1 status) for the presence or absence of the dental characteristics to reduce inconsistencies. By simple association, bulbous crown, periodontitis, and taurodontism were all significant (p < .05). Logistic regression with chi-square maximum likelihood estimates showed that bulbous crown and periodontitis remained significant. Recognition of these phenotypes may aid identification of individuals and families at risk for DICER1-associated neoplasms. These findings may also guide dental care for individuals with germline DICER1 pathogenic variation.

KEYWORDS:

DICER1; bulbous crowns; periodontal disease; syndromes; taurodontism; tooth morphology

PMID:
31313479
PMCID:
PMC6692906
[Available on 2020-09-01]
DOI:
10.1002/ajmg.a.61292

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