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J Neurol. 2019 Nov;266(11):2665-2671. doi: 10.1007/s00415-019-09460-4. Epub 2019 Jul 16.

High openness and high extroversion are linked with better time-based prospective memory in multiple sclerosis.

Author information

1
Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
2
Department of Psychology, University of Campania "Luigi Vanvitelli", Viale Ellittico, 31, 81100, Caserta, Italy.
3
IRCCS Fondazione Santa Lucia, Rome, Italy.
4
Neurology Unit "San Giuseppe Moscati", Hospital Avellino, Avellino, Italy.
5
Department of Psychology, University of Campania "Luigi Vanvitelli", Viale Ellittico, 31, 81100, Caserta, Italy. gabriella.santangelo@unicampania.it.

Abstract

BACKGROUND:

Prospective memory (PM) deficits are often reported in multiple sclerosis (MS), but their relationship with neuropsychological characteristics and personality traits remains to be explored.

OBJECTIVE:

To systematically investigate both time-based and event-based PM abilities in a sample of MS without clinically relevant disability or global cognitive decline and to explore cognitive, neuropsychiatric characteristics and personality traits associated with PM deficits.

METHODS:

Thirty-three patients with MS and 33 healthy individuals were enrolled in the study. All participants underwent a standardized measure of PM to evaluate both time-based and event-based PM. Moreover, patients with MS completed the Brief Repeatable Battery to assess cognitive functioning, the Beck Depression Inventory-II and the Dimensional Apathy Scale to assess neuropsychiatric characteristics, and the NEO Personality Inventory-3 to assess personality traits.

RESULTS:

Individuals with MS demonstrated impaired time-based PM compared to healthy individuals. The regression analysis showed that poor performance in time-based PM was significantly related to lower extroversion and openness traits, whereas poor performance in event-based PM was significantly related to lower visuospatial memory abilities.

CONCLUSIONS:

Low levels of openness and extroversion traits are associated with a greater risk of developing time-based PM deficit. Therefore, personality assessment and behavioural interventions should be encouraged in MS clinical practice.

KEYWORDS:

Apathy; Cognitive functioning; Multiple sclerosis; Personality; Prospective memory

PMID:
31312957
DOI:
10.1007/s00415-019-09460-4

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