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JACC Basic Transl Sci. 2019 Jun 24;4(3):404-421. doi: 10.1016/j.jacbts.2019.02.004. eCollection 2019 Jun.

Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure.

Author information

1
Department of Biomedical Science, University of Missouri-Columbia, Columbia, Missouri.
2
Department of Nutrition and Exercise Physiology, University of Missouri-Columbia, Columbia, Missouri.
3
Department of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri.
4
David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
5
Department of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois.
6
Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri.
7
Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University- School of Medicine, St. Louis, Missouri.
8
Department of Child Health, University of Missouri-Columbia, Columbia, Missouri.
9
Department of Medicine - University of Missouri-Columbia, Columbia, Missouri.
10
Research Service, Harry S Truman Memorial VA Hospital, University of Missouri-Columbia, Columbia, Missouri.

Abstract

The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population. This report provides evidence supporting the hypothesis that Western Diet-fed, aortic-banded Ossabaw swine display an integrated physiological, morphological, and genetic phenotype evocative of cardio-metabolic heart failure. This new preclinical animal model displays a distinctive constellation of findings that are conceivably useful to extending the understanding of how pre-existing cardio-metabolic syndrome can contribute to developing HF.

KEYWORDS:

AB, aortic-banded; CON, control; EDPVR, end-diastolic pressure−volume relationship; EF, ejection fraction; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; IL1RL1, interleukin 1 receptor-like 1; LV, left ventricle; NF, nuclear factor; PTX3, pentraxin-3; WD, Western Diet; cardio-metabolic disease; heart failure; integrative pathophysiology; preclinical model of cardiovascular disease

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