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Bioinformation. 2019 Jun 15;15(6):412-418. doi: 10.6026/97320630015412. eCollection 2019.

Phylogenetic insight of Nonribosomal peptide synthetases (NRPS) Adenylate domain in Antibacterial potential Streptomyces BDUSMP 02 isolated from Pitchavaram Mangrove.

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Department F.A. Forel for Environmental and Aquatic Sciences and Institute of Environmental Sciences, School of Earth and Environmental Sciences, Faculty of Science, University of Geneva, Uni Carl Vogt, 66 Boulevard Carl-Vogt, CH-1211 Geneva 4, Switzerland.
Department of Biotechnology and Genetic Engineering, Bharathidasan University, Tiruchirappalli-620024, Tamil Nadu, India.
Postgraduate and Research Department of Zoology, Jamal Mohamed College, Tiruchirappalli-620020, Tamil Nadu, India.


Identification of gene clusters in Streptomyces holds promise for the discovery of regulatory pathways linked to bioactive metabolites. We isolated a broad-spectrum antibacterial potential Streptomyces sp BDUSMP 02 from mangrove sediment. We further found a distinct of phylogeny pattern for NRPS A-domain in the Streptomyces sp BDUSMP 02. The result suggests that Streptomyces sp BDUSMP 02 has the potential to produce a new type of antibacterial compounds belonging to NRPS type.


Mangrove; NRPS; Phylogeny; Streptomyces; adenylate domain

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