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Bioinformation. 2019 May 30;15(6):394-401. doi: 10.6026/97320630015394. eCollection 2019.

Molecular docking based design of Dengue NS5 methyltransferase inhibitors.

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College of Medicine, University of Hail, Hail, KSA.
Department of Laboratory Medicine College of Applied Medical Science, Al-Baha University, Saudi Arabia.
School of studies in Biotechnology, Jiwaji University, Gwalior, Madhya Pradesh, India.


Dengue is a viral infection caused by RNA infection of the family Flaviviridae and spread by the Aedes mosquitoes. Dengue NS5 methyltransferase is a known drug target for the disease. Therefore, it is of interest to design potential inhibitors for the target using molecular docking analysis. Our analysis shows the binding of compounds STOCK1N-98943, STOCK1N-98872, STOCK1N-98956, STOCK1N-98865, and STOCK1N-98950 with the protein drug target with optimal binding features for further in vitro and in vivo evaluations.


Dengue; IBS; methyltransferase; molecular docking; virtual Screening

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