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Trends Cancer. 2019 Jul;5(7):411-425. doi: 10.1016/j.trecan.2019.05.009. Epub 2019 Jun 18.

The Spatial and Genomic Hierarchy of Tumor Ecosystems Revealed by Single-Cell Technologies.

Author information

1
Department of Molecular and Cellular Biology and Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX 77030, USA.
2
Department of Molecular and Cellular Biology and Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Bioengineering, Rice University, Houston, TX 77005, USA. Electronic address: chodges@bcm.edu.

Abstract

Many malignancies display heterogeneous features that support cancer progression. Emerging high-resolution methods provide a view of heterogeneity that recognizes the influence of diverse cell types and cell states of the tumor microenvironment. Here we outline a hierarchical organization of tumor heterogeneity from a genomic perspective, summarize the origins of spatially patterned metabolic features, and review recent developments in single-cell and spatially resolved techniques for genome-wide study of multicellular tissues. We also discuss how integrating these approaches can yield new insights into human cancer and emerging immune therapies. Applying these technologies for the analysis of primary tumors, patient-derived xenografts, and in vitro systems holds great promise for understanding the hierarchical structure and environmental influences that underlie tumor ecosystems.

KEYWORDS:

epigenetics; genomics; hypoxia; in situ; metabolism; stroma

PMID:
31311656
PMCID:
PMC6689240
[Available on 2020-07-01]
DOI:
10.1016/j.trecan.2019.05.009

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