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Neoplasma. 2019 Jun 28. pii: 181129N908. doi: 10.4149/neo_2018_181129N908. [Epub ahead of print]

Circular RNA circHIPK3 serves as a prognostic marker to promote chronic myeloid leukemia progression.

Author information

1
Department of Hematology, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
2
Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
3
Institute of Transplantation Science, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.

Abstract

Increasing evidence demonstrate that circular RNAs (circRNAs) play critical role in regulation of gene expression, which participate in the pathogenesis of cancer, including chronic myeloid leukemia (CML). In this study, we aimed to investigate the expression profiling of circHIPK3 in CML. We found that circHIPK3 was significantly upregulated in peripheral blood mononuclear cells (PBMC) and serum samples from CML compared with healthy controls. High circHIPK3 expression predicted a poor outcome of CML patients. Further loss-function experiments suggested the oncogenic role of circHIPK3 in CML. Our findings provide insights on the role of circHIPK3 in the development and treatment of CML.

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