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Clin Nucl Med. 2019 Sep;44(9):738-740. doi: 10.1097/RLU.0000000000002736.

18F-FDOPA PET Compared With 123I-Metaiodobenzylguanidine Scintigraphy and 18F-FDG PET in Secreting Sporadic Pheochromocytoma.

Author information

1
From the Department of Endocrinology, l'Institut du Thorax, CHU de Nantes, Hôpital Nord.
2
CRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes.
3
Departments of Digestive and Endocrine Surgery.
4
Nuclear Medicine, CHU de Nantes, Hôtel-Dieu, Nantes, France.

Abstract

We report the case of a 23-year-old man presenting a right hypersecreting pheochromocytoma, falsely negative on F-FDG PET/CT and on I-metaiodobenzylguanidine (I-MIBG) scintigraphy but strongly positive on F-FDOPA PET/CT. Functional imaging has a key role in diagnosis and prognosis of pheochromocytomas, but choosing the most relevant modality remains difficult. Despite its high specificity, I-MIBG has a limited sensitivity. F-FDG can be used, but it is an unspecific tracer, and F-FDG uptake in brown adipose tissue can hinder the analysis. However, F-FDOPA shows very high sensitivity and specificity in pheochromocytomas with fewer drug interferences than I-MIBG.

PMID:
31306205
DOI:
10.1097/RLU.0000000000002736
[Indexed for MEDLINE]

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