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Am J Clin Pathol. 2019 Oct 7;152(5):647-655. doi: 10.1093/ajcp/aqz086.

Study on Diagnostic Values of Astrocyte Elevated Gene 1 (AEG-1) and Glypican 3 (GPC-3) in Hepatocellular Carcinoma.

Author information

1
Department of Pathology, New York University Langone Health, New York.
2
Department of Pathology, University of Rochester Medical Center, Rochester, NY.
3
Department of Physiology and Biophysics, University of Illinois at Chicago.

Abstract

OBJECTIVES:

To investigate the diagnostic potential of AEG-1 and GPC-3 in hepatocellular carcinoma (HCC).

METHODS:

AEG-1 and GPC-3 immunohistochemistry were performed on HCC, adjacent nontumor tissue (ANT), and dysplastic nodules (DN).

RESULTS:

H score of AEG-1 or GPC-3 in HCC was significantly higher than in ANT or DN. In HCC, 92% and 54% showed AEG-1 and GPC-3 positivity, respectively. In ANT, 16.2% were AEG-1 and 7.6% GPC-3 positive. AEG-1 staining was mostly diffuse, whereas GPC-3 frequently showed focal staining. AEG-1 alone showed high sensitivity but low specificity and accuracy. GPC-3, on the other hand, showed high specificity but low sensitivity and accuracy. Combination of both stains boosted the sensitivity, specificity, and accuracy to 94.6%, 89.5%, and 90.5%, respectively, when only diffuse staining was considered as positive.

CONCLUSIONS:

AEG-1 or GPC-3 alone seemed not an ideal marker for HCC. The combination of AEG-1 and GPC-3 might improve early diagnosis of HCC.

KEYWORDS:

AEG-1; Diagnosis; GPC-3; Hepatocellular carcinoma

PMID:
31305883
DOI:
10.1093/ajcp/aqz086

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