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DNA Repair (Amst). 2019 Jul 8:102662. doi: 10.1016/j.dnarep.2019.102662. [Epub ahead of print]

The role of RNA and RNA-related proteins in the regulation of DNA double strand break repair pathway choice.

Author information

1
Departamento de Genética, Universidad de Sevilla, Sevilla, 41080, Spain; Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, 41092, Spain.
2
Departamento de Genética, Universidad de Sevilla, Sevilla, 41080, Spain; Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, 41092, Spain. Electronic address: pablo.huertas@cabimer.es.

Abstract

DNA end resection is a critical step in the repair of DNA double strand breaks. It controls the way the lesion is going to be repaired, thus its regulation has a great importance in maintaining genomic stability. In this review, we focus in recent discoveries in the field that point to a modulation of resection by RNA molecules and RNA-related proteins. Moreover, we aim to reconcile contradictory reports on the positive or negative effect of DNA:RNA hybrids in the resection process.

KEYWORDS:

DNA double strand break repair; Homologous recombination; NHEJ; R-loops; RNA

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