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Clin Nutr. 2019 Jul 4. pii: S0261-5614(19)30280-8. doi: 10.1016/j.clnu.2019.06.024. [Epub ahead of print]

Dietary vs. pharmacological doses of zinc: A clinical review.

Author information

1
School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil. Electronic address: heitoroliveirasantos@gmail.com.
2
CBIOS (Research Center for Biosciences & Health Technologies), Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisboa, Portugal.
3
Health Sciences Department, CUNY Lehman College, Bronx, NY, USA.

Abstract

Zinc deficiency has a global impact on health in both developing and developed countries, especially among children and the elderly. By modulating anti-inflammatory and antioxidant pathways, zinc supplementation is recommended for the treatment of several ailments, such as liver disease, male hypogonadism, cancers, heart disease (e.g. dyslipidemia) and central nervous system disorders; however, the topic of dietary vs. pharmacological doses of zinc remains controversial. This paper provides a detailed critical review of the effects of zinc supplementation in medicinal doses (i.e. >40 mg/d of elemental zinc) on human health. We further highlight the difficulty in achieving a therapeutic dose of zinc from foodstuffs.

KEYWORDS:

Antioxidant supplements; Hypogonadism; Immunonutrition; ZMA; Zinc supplementation

PMID:
31303527
DOI:
10.1016/j.clnu.2019.06.024

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