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J Infect Dis. 2019 Jul 12. pii: jiz364. doi: 10.1093/infdis/jiz364. [Epub ahead of print]

Survivors of Ebola virus disease develop polyfunctional antibody responses.

Author information

1
Ragon Institute of MGH, MIT, and Harvard, Cambridge MA, USA.
2
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans LA, USA.
3
Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.
4
Eastern Polytechnic University, Kenema, Sierra Leone.
5
Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA.
6
Scripps Research Translational Institute, La Jolla, CA, USA.
7
Department of Biostatistics and Bioinformatics, Tulane School of Public Health and Tropical Medicine.
8
Ministry of Health and Sanitation, Freetown, Sierra Leone.

Abstract

BACKGROUND:

Monoclonal antibodies can mediate protection against Ebola virus (EBOV) infection through direct neutralization as well as through the recruitment of innate immune effector functions. However, the antibody functional response following survival of acute EBOV disease has not been well characterized.

METHODS:

Serum antibodies from EVD survivors from Sierra Leone were profiled to capture variation in overall subclass/isotype abundance, neutralizing activity, and innate immune effector functions.

RESULTS:

Antibodies from EVD survivors exhibit robust innate immune effector functions, mediated primarily by IgG1 and IgA1.

CONCLUSIONS:

Development of functional antibodies follows survival of acute EVD.

KEYWORDS:

Ebola virus; antibody; innate immune effector function

PMID:
31301137
DOI:
10.1093/infdis/jiz364

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