Format

Send to

Choose Destination
Parasite. 2019;26:40. doi: 10.1051/parasite/2019040. Epub 2019 Jul 12.

Anopheles bionomics, insecticide resistance mechanisms, and malaria transmission in the Korhogo area, northern Côte d'Ivoire: a pre-intervention study.

Author information

1
Institut Pierre Richet (IPR), Institut National de Santé Publique (INSP), BP 1500 Bouaké, Côte d'Ivoire - Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), Univ Montpellier, CNRS, IRD, BP 64501, Montpellier, France - Faculté des Sciences et Techniques (FAST), Université d'Abomey-Calavi, BP 1604, Cotonou, Benin.
2
Institut de Recherche en Sciences de la Santé (IRSS), BP 545, Bobo Dioulasso, Burkina Faso - Institut Supérieur des Sciences de la Santé, Université Nazi Boni, BP 1091, Bobo-Dioulasso, Burkina Faso.
3
Institut Pierre Richet (IPR), Institut National de Santé Publique (INSP), BP 1500 Bouaké, Côte d'Ivoire.
4
Institut de Recherche en Sciences de la Santé (IRSS), BP 545, Bobo Dioulasso, Burkina Faso.
5
Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), Univ Montpellier, CNRS, IRD, BP 64501, Montpellier, France.
6
Institut Pierre Richet (IPR), Institut National de Santé Publique (INSP), BP 1500 Bouaké, Côte d'Ivoire - Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), Univ Montpellier, CNRS, IRD, BP 64501, Montpellier, France.
7
Faculté des Sciences et Techniques (FAST), Université d'Abomey-Calavi, BP 1604, Cotonou, Benin.
8
Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), Univ Montpellier, CNRS, IRD, BP 64501, Montpellier, France - Institut de Recherche en Sciences de la Santé (IRSS), BP 545, Bobo Dioulasso, Burkina Faso.

Abstract

A better understanding of malaria transmission at a local scale is essential for developing and implementing effective control strategies. In the framework of a randomized controlled trial (RCT), we aimed to provide an updated description of malaria transmission in the Korhogo area, northern Côte d'Ivoire, and to obtain baseline data for the trial. We performed human landing collections (HLCs) in 26 villages in the Korhogo area during the rainy season (September-October 2016, April-May 2017) and the dry season (November-December 2016, February-March 2017). We used PCR techniques to ascertain the species of the Anopheles gambiae complex, Plasmodium falciparum sporozoite infection, and insecticide resistance mechanisms in a subset of Anopheles vectors. Anopheles gambiae s.l. was the predominant malaria vector in the Korhogo area. Overall, more vectors were collected outdoors than indoors (p < 0.001). Of the 774 An. gambiae s.l. tested in the laboratory, 89.65% were An. gambiae s.s. and 10.35% were An. coluzzii. The frequencies of the kdr allele were very high in An. gambiae s.s. but the ace-1 allele was found at moderate frequencies. An unprotected individual living in the Korhogo area received an average of 9.04, 0.63, 0.06 and 0.12 infected bites per night in September-October, November-December, February-March, and April-May, respectively. These results demonstrate that the intensity of malaria transmission is extremely high in the Korhogo area, especially during the rainy season. Malaria control in highly endemic areas such as Korhogo needs to be strengthened with complementary tools in order to reduce the burden of the disease.

PMID:
31298995
PMCID:
PMC6625791
DOI:
10.1051/parasite/2019040
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for EDP Sciences Icon for PubMed Central
Loading ...
Support Center