Format

Send to

Choose Destination
Diabetes Care. 2019 Jul 11. pii: dc190295. doi: 10.2337/dc19-0295. [Epub ahead of print]

Long-term Weight Loss Maintenance in the Continuation of a Randomized Diabetes Prevention Translational Study: The Healthy Living Partnerships to Prevent Diabetes (HELP PD) Continuation Trial.

Author information

1
Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC mvitolin@wakehealth.edu.
2
Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
3
Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC.
4
Department of Biostatistics and Data Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC.

Abstract

OBJECTIVE:

HELP PD was a clinical trial of 301 adults with prediabetes. Participants were randomized to enhanced usual care (EUC) or to a lifestyle weight loss (LWL) intervention led by community health workers that consisted of a 6-month intensive phase (phase 1) and 18 months of maintenance (phase 2). At 24 months, participants were asked to enroll in phase 3 to assess whether continued group maintenance (GM) sessions would maintain improvements realized in phases 1 and 2 compared with self-directed maintenance (SM) or EUC.

RESEARCH DESIGN AND METHODS:

In phase 3, LWL participants were randomly assigned to GM or SM. EUC participants remained in the EUC arm and along with participants in SM, received monthly newsletters. All participants received semiannual dietitian sessions. Anthropometrics and biomarkers were assessed every 6 months. Mixed-effects models were used to assess changes in outcomes over time.

RESULTS:

Eighty-two of the 151 intervention participants (54%) agreed to participate in phase 3; 41 were randomized to GM or SM. Of the 150 EUC participants, 107 (71%) continued. Ninety percent of clinic visits were completed. Over 48 months of additional follow-up, outcomes remained relatively stable in the EUC participants; the GM group was able to maintain body weight, BMI, and waist circumference; and these measures all increased significantly (P < 0.001) in the SM group.

CONCLUSIONS:

Participants in the GM arm maintained weight loss achieved in phases 1 and 2, while those in the SM arm regained weight. Because group session attendance by the participants in the GM arm was low, it is unclear what intervention components led to successful weight maintenance.

PMID:
31296648
DOI:
10.2337/dc19-0295

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center