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J Neurol Neurosurg Psychiatry. 2019 Jul 11. pii: jnnp-2018-320199. doi: 10.1136/jnnp-2018-320199. [Epub ahead of print]

Effects of vitamin D supplementation on cognitive function and blood Aβ-related biomarkers in older adults with Alzheimer's disease: a randomised, double-blind, placebo-controlled trial.

Author information

1
Department of Epidemiology and Biostatistics, School of Public Health,Tianjin Medical University, Tianjin, China.
2
Department of Infectious Diseases, Tianjin Medical University General Hospital, Tianjin, China.
3
Department of Epidemiology and Biostatistics, School of Public Health,Tianjin Medical University, Tianjin, China mf2002245mf@aliyun.com.

Abstract

OBJECTIVE:

Our study aimed to assess the effect of a 12-month vitamin D supplementation on cognitive function and amyloid beta (Aβ)-related biomarkers in subjects with Alzheimer's disease (AD). METHODS : This was a randomised, double-blind, placebo-controlled trial. 210 AD patients were randomly divided into intervention and control groups. Participants received 12-month 800 IU/day of vitamin D or starch granules as placebo. Tests of cognitive performance and Aβ-related biomarkers were measured at baseline, 6 months and 12 months. RESULTS : Repeated-measures analysis of variance showed significant improvements in plasma Aβ42, APP, BACE1, APPmRNA, BACE1mRNA (p<0.001) levels and information, arithmetic, digit span, vocabulary, block design and picture arrange scores (p<0.05) in the intervention group over the control group. According to mixed-model analysis, vitamin D group had significant increase in full scale IQ during follow-up period (p<0.001).

CONCLUSIONS:

Daily oral vitamin D supplementation (800 IU/day) for 12 months may improve cognitive function and decrease Aβ-related biomarkers in elderly patients with AD. Larger scale longer term randomised trials of vitamin D are needed.

TRIAL REGISTRATION NUMBER:

ChiCTR-IIR-16009549.

KEYWORDS:

Alzheimer’s disease; Aβpeptide; cognitive function; randomised controlled trial; vitamin D

PMID:
31296588
DOI:
10.1136/jnnp-2018-320199

Conflict of interest statement

Competing interests: None declared.

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