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Zebrafish. 2019 Jul 11. doi: 10.1089/zeb.2019.1760. [Epub ahead of print]

Evolutionary Origin and Nomenclature of Vertebrate Wnt11-Family Genes.

Author information

1
1 Institute of Neuroscience, University of Oregon, Eugene, Oregon.
2
2 Stowers Institute for Medical Research, Kansas City, Missouri.

Abstract

To adequately connect zebrafish medical models to human biology, it is essential that gene nomenclature reflects gene orthology. Analysis of gene phylogenies and conserved syntenies shows that the zebrafish gene currently called wnt11 (ENSDARG00000004256, ZFIN ID: ZDB-GENE-990603-12) is not the ortholog of the human gene called WNT11 (ENSG00000085741); instead, the gene currently called wnt11r (ENSDARG00000014796, ZFIN ID: ZDB-GENE-980526-249) is the zebrafish ortholog of human WNT11. Genomic analysis of Wnt11-family genes suggests a model for the birth of Wnt11-family gene ohnologs in genome duplication events, provides a mechanism for the death of a Wnt11-family ohnolog in mammals after they diverged from birds, and suggests revised nomenclature to better connect teleost disease models to human biology.

KEYWORDS:

Wnt signaling; Wnt11; Wnt11r; conserved synteny; ohnolog; whole-genome duplication

PMID:
31295059
DOI:
10.1089/zeb.2019.1760

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