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J Hum Reprod Sci. 2019 Apr-Jun;12(2):136-140. doi: 10.4103/jhrs.JHRS_115_18.

Correlation between Serum Progesterone Level on the Day of Ovulation Trigger During In vitro Fertilization and Its Effect on Treatment Outcome.

Author information

Department of ART, 151 Base Hospital, Guwahati, Assam, India.
Department of ART, AH (R and R), New Delhi, India.
Department of Biochemistry, AH (R and R), New Delhi, India.
Department of Lab Medicine, 151 Base Hospital, Guwahati, Assam, India.



Premature luteinization (PL) is defined as a premature rise in serum progesterone concentration on or before the day of ovulation trigger with human chorionic gonadotropin. The incidence of PL varies between 5% and 30% during in vitro fertilization and embryo transfer (IVF-ET).

Materials and Methods:

The prospective observational study comprising 380 patients undergoing IVF-ET. Blood samples were collected for serum progesterone level estimation on the day of ovulation trigger. Ovum pickup was done 36 h later and serum progesterone levels were correlated with IVF-ET outcome.

Study Outcome:

To correlate serum progesterone level on the day of ovulation trigger during IVF and its effect on treatment outcome.


Mean serum progesterone level in the positive pregnancy group and negative pregnancy group was 0.892 ± 0.752 ng/ml and 0.91 ± 0.688 ng/ml, respectively (P = 0.961). The overall incidence of PL was 12.8% with 12.7% and 13.6% in the agonist and antagonist protocol respectively (P = 0.9001). PL incidence was 13.5% and 13.4% in positive pregnancy and negative pregnancy group (P = 0.223).


PL has been associated with 12.8% of the IVF cycles. There was no statistically significant difference observed in the incidence of PL between different IVF stimulation protocols. PL does not seem to affect IVF outcome.


Decreased ovarian reserve; human chorionic gonadotropin; in vitro fertilization; polycystic ovarian syndrome; premature luteinization

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