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PLoS One. 2019 Jul 10;14(7):e0208666. doi: 10.1371/journal.pone.0208666. eCollection 2019.

Relating excitatory and inhibitory neurochemicals to visual perception: A magnetic resonance study of occipital cortex between migraine events.

Author information

1
Department of Optometry & Vision Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
2
Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia.
3
Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia.
4
School of Psychological Science, University of Western Australia, Perth, Western Australia, Australia.

Abstract

Certain perceptual measures have been proposed as indirect assays of brain neurochemical status in people with migraine. One such measure is binocular rivalry, however, previous studies have not measured rivalry characteristics and brain neurochemistry together in people with migraine. This study compared spectroscopy-measured levels of GABA and Glx (glutamine and glutamate complex) in visual cortex between 16 people with migraine and 16 non-headache controls, and assessed whether the concentration of these neurochemicals explains, at least partially, inter-individual variability in binocular rivalry perceptual measures. Mean Glx level was significantly reduced in migraineurs relative to controls, whereas mean occipital GABA levels were similar between groups. Neither GABA levels, nor Glx levels correlated with rivalry percept duration. Our results thus suggest that the previously suggested relationship between rivalry percept duration and GABAergic inhibitory neurotransmitter concentration in visual cortex is not strong enough to enable rivalry percept duration to be reliably assumed to be a surrogate for GABA concentration, at least in the context of healthy individuals and those that experience migraine.

PMID:
31291247
DOI:
10.1371/journal.pone.0208666
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Conflict of interest statement

I have read the journal’s policy and the authors of this manuscript have the following competing interests: Yu Man Chan reports no disclosures. Kabilan Pitchaimuthu received Melbourne International Research Scholarship and Melbourne International Fee Remission Scholarship from the University of Melbourne. Qi-Zhu Wu is an employee of Shenzhen Sinorad Medical Electronics Inc., Shenzhen, China. Olivia Carter is funded by Australian Research Council Future Fellowship grant #FT140100807 Gary Egan receives funding support from the Australian Research Council Centre of Excellence in Integrative Brain Function (CE140100007) David R. Badcock is funded by the Australian NHMRC (APP1081874) and Australian Research Council (DP160104211). Allison M McKendrick receives research support from Heidelberg Engineering GmBH (Germany), CenterVue PdA (Italy), and Haag-Streit AG (Switzerland), and has research funding from the Australian Research Council and Australian National Health and Medical Research Council (APP1081874), and is an editorial board member of the following journals: Graefe’s Archive of Clinical & Experimental Ophthalmology, Clinical & Experimental Optometry; and Translational Vision Science Technology.

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