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J Headache Pain. 2019 Jul 9;20(1):77. doi: 10.1186/s10194-019-1026-8.

Fluctuations of sensorimotor processing in migraine: a controlled longitudinal study of beta event related desynchronization.

Author information

1
Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway. martin.s.mykland@ntnu.no.
2
Department of Clinical Medicine, University of Bergen, Bergen, Norway.
3
Department of Neurology, Haukeland University Hospital, Bergen, Norway.
4
Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
5
Department of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim, Norway.

Abstract

BACKGROUND:

The migraine brain seems to undergo cyclic fluctuations of sensory processing. For instance, during the preictal phase, migraineurs experience symptoms and signs of altered pain perception as well as other well-known premonitory CNS-symptoms. In the present study we measured EEG-activation to non-painful motor and sensorimotor tasks in the different phases of the migraine cycle by longitudinal measurements of beta event related desynchronization (beta-ERD).

METHODS:

We recorded electroencephalography (EEG) of 41 migraine patients and 31 healthy controls. Each subject underwent three EEG recordings on three different days with classification of each EEG recording according to the actual migraine phase. During each recording, subjects performed one motor and one sensorimotor task with the flexion-extension movement of the right wrist.

RESULTS:

Migraine patients had significantly increased beta-ERD and higher baseline beta power at the contralateral C3 electrode overlying the primary sensorimotor cortex in the preictal phase compared to the interictal phase. We found no significant differences in beta-ERD or baseline beta power between interictal migraineurs and controls.

CONCLUSION:

Increased preictal baseline beta activity may reflect a decrease in pre-activation in the sensorimotor cortex. Altered pre-activation may lead to changes in thresholds for inhibitory responses and increased beta-ERD response, possibly reflecting a generally increased preictal cortical responsivity in migraine. Cyclic fluctuations in the activity of second- and third-order afferent somatosensory neurons, and their associated cortical and/or thalamic interneurons, may accordingly also be a central part of the migraine pathophysiology.

KEYWORDS:

Cortex; Cycle; EEG; ERD; Headache; Migraine; Neurophysiology; Pathophysiology; Pre-activation; Thalamus

PMID:
31288756
DOI:
10.1186/s10194-019-1026-8
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