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Curr Mol Med. 2019;19(8):539-546. doi: 10.2174/1566524019666190709172636.

Stem Cells as a Resource for Treatment of Infertility-related Diseases.

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Reproductive Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Department of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.


Worldwide, infertility affects 8-12% of couples of reproductive age and has become a common problem. There are many ways to treat infertility, including medication, intrauterine insemination, and in vitro fertilization. In recent years, stem-cell therapy has raised new hope in the field of reproductive disability management. Stem cells are self-renewing, self-replicating undifferentiated cells that are capable of producing specialized cells under appropriate conditions. They exist throughout a human's embryo, fetal, and adult stages and can proliferate into different cells. While many issues remain to be addressed concerning stem cells, stem cells have undeniably opened up new ways to treat infertility. In this review, we describe past, present, and future strategies for the use of stem cells in reproductive medicine.


ICSI; IUI; IVF; Infertility; World Health Organization (WHO); fertilization; stem cells.

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