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Curr Mol Med. 2019;19(6):387-394. doi: 10.2174/1566524019666190429144310.

Exosome: An Emerging Source of Biomarkers for Human Diseases.

Xu L1,2, Wu LF1,2, Deng FY1,2.

Author information

1
Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, P. R., China.
2
Jiangsu Key Laboratory of Preventive and Translational Medicine for G eriatric Diseases, Soochow University, Suzhou, Jiangsu 215123, P.R. China.

Abstract

Exosomes are 30-120nm long endocytic membrane-derived vesicles, which are secreted by various types of cells and stably present in body fluids, such as plasma, urine, saliva and breast milk. Exosomes participate in intercellular communication. Recently accumulative studies have suggested that exosomes may serve as novel biomarkers for disease diagnosis and prognosis. Herein, we reviewed the biological features of exosomes, technologies for exosome isolation and identification, as well as progress in exosomal biomarker identification, highlighting the relevance of exosome to human diseases and significance and great potential in translational medicine.

KEYWORDS:

Biomarker; Diagnosis; Exosome; Isolation; Protein; RNA.

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