Exosome: An Emerging Source of Biomarkers for Human Diseases

Li Xu; Long-Fei Wu; Fei-Yan Deng

doi:10.2174/1566524019666190429144310

Exosome: An Emerging Source of Biomarkers for Human Diseases

Curr Mol Med. 2019;19(6):387-394. doi: 10.2174/1566524019666190429144310.

Authors

Li Xu^{1

2}, Long-Fei Wu^{1

2}, Fei-Yan Deng^{1

2}

Affiliations

¹ Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, P. R., China.
² Jiangsu Key Laboratory of Preventive and Translational Medicine for G eriatric Diseases, Soochow University, Suzhou, Jiangsu 215123, P.R. China.

PMID: 31288712
DOI: 10.2174/1566524019666190429144310

Abstract

Exosomes are 30-120nm long endocytic membrane-derived vesicles, which are secreted by various types of cells and stably present in body fluids, such as plasma, urine, saliva and breast milk. Exosomes participate in intercellular communication. Recently accumulative studies have suggested that exosomes may serve as novel biomarkers for disease diagnosis and prognosis. Herein, we reviewed the biological features of exosomes, technologies for exosome isolation and identification, as well as progress in exosomal biomarker identification, highlighting the relevance of exosome to human diseases and significance and great potential in translational medicine.

Keywords: Biomarker; Diagnosis; Exosome; Isolation; Protein; RNA..

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biomarkers*
Cell Fractionation / methods
Exosomes / metabolism*
Humans
Liquid Biopsy / methods
Liquid Biopsy / standards
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Precision Medicine
Translational Research, Biomedical

Substances

Biomarkers