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Pediatr Int. 2019 Jul 9. doi: 10.1111/ped.13958. [Epub ahead of print]

How does dynamic thiol/disulphide homeostasis work in the pathogenesis of Kawasaki disease?

Author information

1
Department of Pediatric Infectious Disease, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
2
Department of Biochemistry, Yildirim Beyazit University School of Medicine.

Abstract

INTRODUCTION:

Kawasaki disease (KD) is an acute, self-limited, systemic vasculitis of unknown etiology. In the present study, we questioned if there is a relationship between KD and dynamic thiol/disulphide homeostasis.

METHODS:

This case control study inclueded KD patients and healthy controls. Plasma total, native and disulphide thiol levels and the disulphide/native, disulphide/total and native thiol/ total thiol ratios of all patients and control group were analyzed simultaneously.

RESULTS:

A total of 20 patients with KD (male/female: 12/8) and 25 (male/female: 12/13) age and gender matched healthy controls were evaluated. Native, total thiol and native thiol/total thiol ratio were significantly lower in KD patients than control group (p<0.001). On the other hand, disulphide thiol level, disulphide/native thiol and disulphide/total thiol ratios were statistically higher in patients than control subjects (p<0.001).In patients with coronary artery lesion (CAL) the native thiol and total thiol levels were significantly lower than patient without CAL. In patients with CAL, the ratios of disulfide/total thiol and disulfide/native thiol were significantly higher than those without CAL (p = 0.02 and p = 0.02, respectively), whereas the ratio of native / total thiol was significantly lower (p = 0.02).

CONCLUSION:

We detected lower plasma thiol (native and total) and higher disulphide thiol levels in KD patients than in controls, indicating that dynamic thiol/disulphide homeostasis might be an important indicator of inflammation in KD. Alteration and shifting of thiol/disulphide homeostasis to the oxidized side is correlated to the pathogenesis of KD and CAL. This article is protected by copyright. All rights reserved.

KEYWORDS:

Coronary artery lesion; Kawasaki Disease; pathogenesis; thiol/disulphide homeostasis

PMID:
31287938
DOI:
10.1111/ped.13958

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