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Pediatr Int. 2019 Jul 9. doi: 10.1111/ped.13958. [Epub ahead of print]

How does dynamic thiol/disulphide homeostasis work in the pathogenesis of Kawasaki disease?

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Department of Pediatric Infectious Disease, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
Department of Biochemistry, Yildirim Beyazit University School of Medicine.



Kawasaki disease (KD) is an acute, self-limited, systemic vasculitis of unknown etiology. In the present study, we questioned if there is a relationship between KD and dynamic thiol/disulphide homeostasis.


This case control study inclueded KD patients and healthy controls. Plasma total, native and disulphide thiol levels and the disulphide/native, disulphide/total and native thiol/ total thiol ratios of all patients and control group were analyzed simultaneously.


A total of 20 patients with KD (male/female: 12/8) and 25 (male/female: 12/13) age and gender matched healthy controls were evaluated. Native, total thiol and native thiol/total thiol ratio were significantly lower in KD patients than control group (p<0.001). On the other hand, disulphide thiol level, disulphide/native thiol and disulphide/total thiol ratios were statistically higher in patients than control subjects (p<0.001).In patients with coronary artery lesion (CAL) the native thiol and total thiol levels were significantly lower than patient without CAL. In patients with CAL, the ratios of disulfide/total thiol and disulfide/native thiol were significantly higher than those without CAL (p = 0.02 and p = 0.02, respectively), whereas the ratio of native / total thiol was significantly lower (p = 0.02).


We detected lower plasma thiol (native and total) and higher disulphide thiol levels in KD patients than in controls, indicating that dynamic thiol/disulphide homeostasis might be an important indicator of inflammation in KD. Alteration and shifting of thiol/disulphide homeostasis to the oxidized side is correlated to the pathogenesis of KD and CAL. This article is protected by copyright. All rights reserved.


Coronary artery lesion; Kawasaki Disease; pathogenesis; thiol/disulphide homeostasis


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