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AIDS Behav. 2019 Jul 8. doi: 10.1007/s10461-019-02585-7. [Epub ahead of print]

HCV-Related Mortality Among HIV/HCV Co-infected Patients: The Importance of Behaviors in the HCV Cure Era (ANRS CO13 HEPAVIH Cohort).

Collaborators (270)

Salmon D, Wittkop L, Sogni P, Esterle L, Trimoulet P, Izopet J, Serfaty L, Paradis V, Spire B, Carrieri P, Valantin MA, Pialoux G, Chas J, Poizot-Martin I, Barange K, Naqvi A, Rosenthal E, Bicart-See A, Bouchaud O, Gervais A, Lascoux-Combe C, Goujard C, Lacombe K, Duvivier C, Vittecoq D, Neau D, Morlat P, Bani-Sadr F, Meyer L, Boufassa F, Dominguez S, Autran B, Roque AM, Solas C, Fontaine H, Costagliola D, Piroth L, Simon A, Zucman D, Boué F, Miailhes P, Billaud E, Aumaître H, Rey D, Peytavin G, Petrov-Sanchez V, Pailhé A, Salmon D, Usubillaga R, Sogni P, Terris B, Tremeaux P, Katlama C, Stitou H, Benhamou Y, Charlotte F, Fourati S, Simon A, Cacoub P, Nafissa S, Poizot-Martin I, Zaegel O, Laroche H, Tamalet C, Pialoux G, Chas J, Callard P, Bendjaballah F, Le Pendeven C, Marchou B, Alric L, Metivier S, Selves J, Larroquette F, Rosenthal E, Naqvi A, Rio V, Haudebourg J, Saint-Paul MC, Partouche C, Bouchaud O, Ziol M, Baazia Y, Uzan M, Garipuy D, Ferro-Collados MJ, Nicot F, Yazdanpanah Y, Adle-Biassette H, Alexandre G, Lascoux-Combe C, Molina JM, Bertheau P, Chaix ML, Delaugerre C, Maylin S, Bottero J, Krause J, Girard PM, Wendum D, Cervera P, Adam J, Viala C, Goujard C, Quertainmont Y, Teicher E, Pallier C, Vittecoq D, Lortholary O, Rouzaud C, Lourenco J, Touam F, Louisin C, Avettand-Fenoel V, Mélard A, Neau D, Ochoa A, Blanchard E, Castet-Lafarie S, Cazanave C, Malvy D, Dupon M, Dutronc H, Dauchy F, Lacaze-Buzy L, Bioulac-Sage P, Reigadas S, Morlat P, Lacoste D, Bonnet F, Bernard N, Hessamfar M, Paccalin F, Martell C, Pertusa MC, Vandenhende M, Merciéer P, Pistone T, Receveur MC, Méchain M, Duffau P, Rivoisy C, Faure I, Caldato S, Pellegrin JL, Viallard JF, Lazzaro E, Greib C, Zucman D, Majerholc C, Farfour E, Boué F, Polo Devoto J, Kansau I, Chambrin V, Pignon C, Berroukeche L, Fior R, Martinez V, Deback C, Lévy Y, Lelièvre JD, Lascaux AS, Melica G, Billaud E, Raffi F, Allavena C, Reliquet V, Boutoille D, Biron C, Rodallec A, Le Guen L, Miailhes P, Peyramond D, Chidiac C, Ader F, Biron F, Boibieux A, Cotte L, Ferry T, Perpoint T, Koffi J, Zoulim F, Bailly F, Lack P, Maynard M, Radenne S, Amiri M, Scholtes C, Le-Thi TT, Chavanet P, Van Huyen MD, Buisson M, Waldner-Combernoux A, Mahy S, Binois R, Simonet-Lann AL, Croisier-Bertin D, Aumaître H, Bani-Sadr F, Lambert D, Nguyen Y, Berger JL, Rey D, Partisani M, Batard ML, Cheneau C, Priester M, Bernard-Henry C, de Mautort E, Gantner P, Fafi-Kremer S, Peytavin G, Roustant F, Kmiec I, Traore L, Lepuil S, Parlier S, Sicart-Payssan V, Bedel E, Louisin C, Mole M, Bolliot C, Mebarki M, Adda-Lievin A, Makhoukhi FZ, Braik O, Bayoud R, Pietri MP, Le Baut V, Bornarel D, Chesnel C, Beniken D, Pauchard M, Akel S, Caldato S, Lions C, Chalal L, Julia Z, Hue H, Soria A, Cavellec M, Breau S, Joulie A, Fisher P, Ondo Eyene C, Ogoudjobi S, Brochier C, Thoirain-Galvan V, Boerg E, Conte V, Dequae-Merchadou L, Desvallees M, Douiri N, Esterle L, Gilbert C, Gillet S, Knight R, Marcellin F, Michel L, Mora M, Protopopescu C, Roux P, Tezkratt S, Yaya I, Barré T, Rojas Rojas T, Villes V, Baudoin M, Santos M.

Author information

1
Faculdade de Ciências da Saúde, Universidade de Brasília, Brasília, Brazil.
2
INSERM, IRD, SESSTIM, Sciences Economiques, & Sociales de la Santé & Traitement de l'Information Médicale, Aix Marseille Université, Marseille, France.
3
Observatoire régional de la santé Provence-Alpes-Côte d'Azur, ORS PACA, Marseille, France.
4
Service d'Hépatologie, Hôpital Cochin, AP-HP, Paris, France.
5
INSERM U-1223, Institut Pasteur, Paris, France.
6
Université Paris Descartes - Sorbonne Paris Cité, Paris, France.
7
Département d'Infectiologie, CHU de Dijon, Dijon, France.
8
INSERM - CIC 1342, Université de Bourgogne, Dijon, France.
9
Service d'Hépatologie et Gastroentérologie, Hôpital de la Croix-Rousse, Lyon, France.
10
INSERM U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
11
Bordeaux Population Health Research Center, INSERM U1219, CIC-EC 1401, Univ. Bordeaux - ISPED, Bordeaux, France.
12
Service d'information médicale, CHU de Bordeaux, Bordeaux, France.
13
Service de Médecine Interne, Hôpital l'Archet, CHU de Nice, Nice, France.
14
LAMHESS, Université de Nice-Sophia Antipolis, Nice, France.
15
Service de Médecine Interne et Maladies Infectieuses, CHU de Bordeaux, Bordeaux, France.
16
Faculdade UnB Ceilândia, Universidade de Brasília, Brasília, Brazil.
17
Service de Maladies Infectieuses et Tropicales, Hôpital Cochin, AP-HP, Paris, France.
18
INSERM, IRD, SESSTIM, Sciences Economiques, & Sociales de la Santé & Traitement de l'Information Médicale, Aix Marseille Université, Marseille, France. pmcarrieri@aol.com.
19
Observatoire régional de la santé Provence-Alpes-Côte d'Azur, ORS PACA, Marseille, France. pmcarrieri@aol.com.

Abstract

Mortality among individuals co-infected with HIV and hepatitis C virus (HCV) is relatively high. We evaluated the association between psychoactive substance use and both HCV and non-HCV mortality in HIV/HCV co-infected patients in France, using Fine and Gray's competing-risk model adjusted for socio-demographic, clinical predictors and confounding factors, while accounting for competing causes of death. Over a 5-year median follow-up period, 77 deaths occurred among 1028 patients. Regular/daily cannabis use, elevated coffee intake, and not currently smoking were independently associated with reduced HCV-mortality (adjusted sub-hazard ratio [95% CI] 0.28 [0.10-0.83], 0.38 [0.15-0.95], and 0.28 [0.10-0.79], respectively). Obesity and severe thinness were associated with increased HCV-mortality (2.44 [1.00-5.93] and 7.25 [2.22-23.6] versus normal weight, respectively). Regular binge drinking was associated with increased non-HCV-mortality (2.19 [1.10-4.37]). Further research is needed to understand the causal mechanisms involved. People living with HIV/HCV co-infection should be referred for tobacco, alcohol and weight control interventions and potential benefits of cannabis-based therapies investigated.

KEYWORDS:

Behavior; HIV; Hepatitis C; Mortality; Substance use

PMID:
31286317
DOI:
10.1007/s10461-019-02585-7

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