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J Exp Neurosci. 2019 Jun 27;13:1179069519856876. doi: 10.1177/1179069519856876. eCollection 2019.

Adult Neurogenesis and the Promise of Adult Neural Stem Cells.

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1
National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India.

Abstract

The adult brain, even though largely postmitotic, is now known to have dividing cells that can make both glia and neurons. Of these, the precursor cells that have the potential to make new neurons in the adult brain have attracted great attention from researchers, anticipating their therapeutic potential for neurodegenerative conditions. In this review, I will focus on adult neurogenesis, from the perspective of the overall neurogenic potential in the adult brain, current understanding of the 'adult neural stem cell', and the importance of niche as a decisive factor for neurogenesis under homeostasis and pathologic conditions.

KEYWORDS:

astrocyte; dentate gyrus; fate potential; glia; hippocampus; neural stem cell; neurogenesis; niche; radial glia; regeneration; transplantation

Conflict of interest statement

Declaration of Conflicting Interests:The author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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