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Bioinformation. 2019 Apr 15;15(4):299-306. doi: 10.6026/97320630015299. eCollection 2019.

A comparative analysis of BCL-2 family.

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Department of Biotechnology, Assam University, Silchar-788011, Assam, India.


The BCL-2 family is conserved in evolution and shares a BCL-2 homology domain. It promotes and inhibits apoptosis. It is also known that apoptosis has a major role in effective cancer treatment. Therefore, it is of interest to document information related to the BCL-2 family of proteins for analysis by prediction tools. Hence, insights from a prediction based comparative functional analysis of 108 genes in this family are documented.


BCL-2 family; anti-apoptotic; divergent genes; pro-apoptotic

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