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Nat Med. 2019 Aug;25(8):1213-1217. doi: 10.1038/s41591-019-0496-1. Epub 2019 Jul 8.

Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children.

Author information

1
David Geffen UCLA School of Medicine, CA, Los Angeles, USA. knielsen@mednet.ucla.edu.
2
Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
3
David Geffen UCLA School of Medicine, CA, Los Angeles, USA.
4
Biomedical Research Institute of Southern California, CA, Oceanside, USA.
5
Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
6
Medical University of Graz, Graz, Austria.
7
University Medical Center, Göttingen, Germany.
8
UCSF School of Medicine, CA, San Francisco, USA.
9
State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
10
Parkinson's Disease Center, Beijing Institute for Brain Disorders, Beijing, China.
11
Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. bebethiff@gmail.com.

Abstract

We report neurodevelopmental outcomes in 216 infants followed since the time of PCR-confirmed maternal Zika virus (ZIKV) infection in pregnancy during the Rio de Janeiro epidemic of 2015-2016 (refs. 1,2). Neurodevelopment was assessed by Bayley Scales of Infant and Toddler Development, third edition (Bayley-III; cognitive, language and motor domains) in 146 children and through neurodevelopment questionnaires/neurological examinations in 70 remaining children. Complete eye exams (n = 137) and hearing assessments (n = 114) were also performed. Below-average neurodevelopment and/or abnormal eye or hearing assessments were noted in 31.5% of children between 7 and 32 months of age. Among children assessed by Bayley-III, 12% scored below -2 s.d. (score <70; a score of 100 ± 2 s.d. is the range) in at least one domain; and 28% scored between -1 and -2 s.d. in any domain (scores <85-70). Language function was most affected, with 35% of 146 children below average. Improved neurodevelopmental outcomes were noted in female children, term babies, children with normal eye exams and maternal infection later in pregnancy (P = 0.01). We noted resolution of microcephaly with normal neurodevelopment in two of eight children, development of secondary microcephaly in two other children and autism spectrum disorder in three previously healthy children in the second year of life.

PMID:
31285631
PMCID:
PMC6689256
[Available on 2020-01-08]
DOI:
10.1038/s41591-019-0496-1
[Indexed for MEDLINE]

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