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Eur J Hum Genet. 2019 Jul 8. doi: 10.1038/s41431-019-0466-6. [Epub ahead of print]

Genetic relationships of European, Mediterranean, and SW Asian populations using a panel of 55 AISNPs.

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Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Turkish Cypriot DNA Laboratory, Committee on Missing Persons in Cyprus Turkish Cypriot Member Office, Nicosia, North Cyprus, Turkey.
Dr. Fazıl Küçük Faculty of Medicine, Eastern Mediterranean University, Famagusta, North Cyprus, Turkey.
Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina.
Mendel Center for Biomedical Sciences, Egkomi, Nicosia, Cyprus.
Laboratory of Genetics, Immunology and Human Pathologies, Faculty of Sciences of Tunis, University of Tunis El Manar, 2092, Tunis, Tunisia.
Higher Institute of Biotechnology of Monastir, Monastir University, 5000, Monastir, Tunisia.
Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar.
Centre for Forensic Genetics, Institute of Medical Biology, UiT -The Arctic University of Norway, Tromsø, Norway.
School of Forensic & Applied Sciences, University of Central Lancashire, Preston, UK.
Ministry of Interior of Qatar, Doha, Qatar.
Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2100, Copenhagen, Denmark.
Institute of Forensic Science, Istanbul University, Istanbul, Turkey.
Center for Medical Informatics, Yale University School of Medicine, New Haven, CT, 06520, USA.
Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.


The set of 55 ancestry informative SNPs (AISNPs) originally developed by the Kidd Lab has been studied on a large number of populations and continues to be applied to new population samples. The existing reference database of population samples allows the relationships of new population samples to be inferred on a global level. Analyses show that these autosomal markers constitute one of the better panels of AISNPs. Continuing to build this reference database enhances its value. Because more than half of the 25 ethnic groups recently studied with these AISNPs are from Southwest Asia and the Mediterranean region, we present here various analyses focused on populations from these regions along with selected reference populations from nearby regions where genotype data are available. Many of these ethnic groups have not been previously studied for forensic markers. Data on populations from other world regions have also been added to the database but are not included in these focused analyses. The new population samples added to ALFRED and FROG-kb increase the total to 164 population samples that have been studied for all 55 AISNPs.


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