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Diagn Microbiol Infect Dis. 2019 Jun 15:114851. doi: 10.1016/j.diagmicrobio.2019.06.003. [Epub ahead of print]

Detection of NDM-19, a novel variant of the New Delhi metallo-β-lactamase with increased carbapenemase activity under zinc-limited conditions, in Switzerland.

Author information

1
University of Zurich, Institute of Medical Microbiology, Zurich, Switzerland. Electronic address: smancini@imm.uzh.ch.
2
University of Zurich, Institute of Medical Microbiology, Zurich, Switzerland.
3
University of Zurich, University Hospital of Zurich, Division of Infectious Diseases and Hospital Epidemiology, Zurich, Switzerland.

Abstract

A novel New Delhi metallo-β-lactamase (NDM) variant, NDM-19, was identified in a carbapenem-resistant E. coli strain isolated from a subcutaneous infection of a laparotomy scar from an Egyptian patient in a Swiss hospital. NDM-19 is a derivative of NDM-7, from which it differs by a single amino acid substitution (Ala233Val). Under zinc-limiting growth conditions, E. coli DH5α transformants producing NDM-19 displayed reduced susceptibility towards expanded-spectrum cephalosporins and carbapenems as compared to transformants producing NDM-1 or NDM-7.

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