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Curr Med Chem. 2019 Jul 5. doi: 10.2174/0929867326666190705155854. [Epub ahead of print]

Graphene and graphene-based materials in biomedical applications.

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Center of Nanotechnology, King Abdulaziz University, Jeddah. Saudi Arabia.
Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah. Saudi Arabia.
King Fahd Armed Forces Hospital, Jeddah. Saudi Arabia.
Department of Chemical Engineering, Northeastern University, Boston. United States.


Recently, there have been huge advancements in the field of nanobiotechnology. One of the main drivers has been the development of novel nanomaterials. One new class of materials is graphene and its derivatives recognized for their novel properties present on the nanoscale. In particular, graphene and graphene-based nanomaterials have been shown to have excellent electrical, mechanical, optical and thermal properties. Due to these unique properties coupled with the ability to tune their biocompatibility, these nanomaterials have been propelled for various applications. Most recently these two-dimensional nanomaterials have been widely recognized for their utility in biomedical research. In this review, we first give a brief overview of the strategies to synthesize graphene and its derivatives. Next, we discuss the biocompatibility profile of these nanomaterials as a precursor to their biomedical application. Finally, we highlight recent applications of graphene-based nanomaterials in various biomedical fields including tissue engineering, drug and gene delivery, biosensing and bioimaging as well as other bio-related studies.


biocompatibility; biomedical applications; drug delivery; graphene; graphene oxide; nanomaterials; tissue engineering

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