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Mol Aspects Med. 2019 Aug;68:90-100. doi: 10.1016/j.mam.2019.07.001. Epub 2019 Jul 16.

The role of brown and beige adipose tissue in glycaemic control.

Author information

1
Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, Inner Medicine 1, Heidelberg, Germany; Deutsches Zentrum für Diabetesforschung, Neuherberg, Germany.
2
Deutsches Zentrum für Diabetesforschung, Neuherberg, Germany.
3
Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, Inner Medicine 1, Heidelberg, Germany; Deutsches Zentrum für Diabetesforschung, Neuherberg, Germany; Chair Molecular Metabolic Control, Technical University Munich, Germany. Electronic address: stephan.herzig@helmholtz-muenchen.de.

Abstract

For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting the so-called batokines to communicate with other metabolic tissues and regulate systemic energy homeostasis. However, despite numerous studies showing the benefits of BAT in rodents, it is still not clear whether recruitment of BAT can be utilized to treat human patients. Here, we review the advances on understanding the role of BAT in metabolism and its benefits on glucose and lipid homeostasis in both humans and rodents. Moreover, we discuss the latest methodological approaches to assess the contribution of BAT to human metabolism as well as the possibility to target BAT, pharmacologically or by lifestyle adaptations, to treat metabolic disorders.

KEYWORDS:

Antiobesity therapies; Batokines; Brown adipose tissue; Clinical and basic science research; Glucose homeostasis; Lipid homeostasis

PMID:
31283940
DOI:
10.1016/j.mam.2019.07.001

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