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Open Forum Infect Dis. 2019 Jun 1;6(7):ofz263. doi: 10.1093/ofid/ofz263. eCollection 2019 Jul.

Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia.

Author information

1
Global and Tropical Health Division, Menzies School of Health Research, Darwin, Australia.
2
Department of Infectious Diseases, Royal Darwin Hospital, Darwin, Australia.
3
Department of Pathology, Royal Darwin Hospital, Darwin, Australia.
4
GeneCology Research Centre, University of the Sunshine Coast, Sippy Downs, Australia.
5
Department of Infectious Diseases, John Hunter Hospital and the University of Newcastle, Newcastle, Australia.

Abstract

Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3-56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.

KEYWORDS:

Acinetobacter baumannii; community-acquired pneumonia; recurrence; relapse; whole-genome sequencing

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