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Dig Liver Dis. 2019 Jul 4. pii: S1590-8658(19)30662-0. doi: 10.1016/j.dld.2019.06.005. [Epub ahead of print]

Dietary vitamin E and C intake is inversely associated with the severity of nonalcoholic fatty liver disease.

Author information

1
School of Public Health, University of Haifa, Haifa, Israel. Electronic address: szelber-s@univ.haifa.ac.il.
2
Department of Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv, Israel. Electronic address: naomifl@tlvmc.gov.il.
3
Division of Gastroenterology, Ospedale di Acireale, Azienda Sanitaria Provinciale di Catania, Catania, Italy. Electronic address: federicosalomone@rocketmail.com.
4
Department of Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv, Israel; The Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: murielw@tlvmc.gov.il.
5
Department of Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv, Israel; The Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: orensh@tlvmc.gov.il.
6
Department of Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv, Israel; The Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: revitalk@tlvmc.gov.il.
7
School of Public Health, University of Haifa, Haifa, Israel; Department of Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv, Israel. Electronic address: zelbersagi@bezeqint.net.

Abstract

BACKGROUND & AIMS:

Although antioxidants have a protective potential in nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH), there is limited evidence regarding the role of dietary intake of antioxidants. The aim was to test the association between dietary vitamins E and C intake and NAFLD, NASH and fibrosis markers.

METHODS:

Cross-sectional study of a large cohort of subjects undergoing colonoscopy. The presence of NAFLD was evaluated by ultrasonography. The level of steatosis was defined using SteatoTest, moderate-severe NASH using new quantitative NashTest and borderline-significant fibrosis ≥ F1-F2 using FibroTest. Nutritional intake was measured by food frequency questionnaire (FFQ).

RESULTS:

Overall, 789 subjects were included (52.6% men, age 58.83 ± 6.58 years), 714 had reliable FibroMax. Adjusting for BMI, dietary and lifestyle factors, the upper tertile of vitamin E intake/1000 Kcal was associated with lower odds of NASH (OR = 0.64, 0.43-0.94, P = 0.024). There was an inverse association between reaching the recommended vitamin E intake and NASH (OR = 0.48, 0.30-0.77, P = 0.002). The upper tertile of vitamin C intake/1000 Kcal was associated with lower odds of NAFLD and NASH (OR = 0.68, 0.47-0.99, P = 0.045; OR = 0.57, 0.38-0.84, P = 0.004, respectively). Both vitamins were related with the level of steatosis according to SteatoTest.

CONCLUSION:

Vitamin E and C intake may be protective from NAFLD-related liver damage.

KEYWORDS:

Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Vitamin C; Vitamin E

PMID:
31281067
DOI:
10.1016/j.dld.2019.06.005

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