Rapid response to 2'-deoxycoformycin in advanced hairy cell leukemia after failure of interferons alpha and gamma

B C Lembersky; M J Ratain; C Westbrook; H M Golomb

doi:10.1002/ajh.2830270114

Rapid response to 2'-deoxycoformycin in advanced hairy cell leukemia after failure of interferons alpha and gamma

Am J Hematol. 1988 Jan;27(1):60-2. doi: 10.1002/ajh.2830270114.

Authors

B C Lembersky¹, M J Ratain, C Westbrook, H M Golomb

Affiliation

¹ Department of Medicine, University of Chicago Pritzker School of Medicine, IL.

PMID: 3128105
DOI: 10.1002/ajh.2830270114

Abstract

A patient with advanced hairy cell leukemia initially had a short-lived minor response to interferon alpha therapy and failed to respond to interferon gamma. Subsequent treatment with 2'-deoxycoformycin (dCF) administered biweekly for 12 wk resulted in a complete hematological remission which has continued for 16 months without additional therapy.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / therapeutic use*
Coformycin / analogs & derivatives
Coformycin / therapeutic use*
Drug Resistance
Humans
Interferon Type I / therapeutic use*
Interferon-gamma / therapeutic use*
Leukemia, Hairy Cell / drug therapy*
Leukemia, Hairy Cell / pathology
Male
Middle Aged
Pentostatin
Remission Induction
Ribonucleosides / therapeutic use*

Substances

Antineoplastic Agents
Interferon Type I
Ribonucleosides
Coformycin
Pentostatin
Interferon-gamma