Format

Send to

Choose Destination
Trends Endocrinol Metab. 2019 Sep;30(9):636-645. doi: 10.1016/j.tem.2019.06.002. Epub 2019 Jul 3.

Epigenetics and Exercise.

Author information

1
Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong Waurn Ponds, VIC 3216, Australia. Electronic address: sean.mcgee@deakin.edu.au.
2
Department of Physiology, The University of Melbourne, VIC 3010, Australia. Electronic address: m.hargreaves@unimelb.edu.au.

Abstract

Epigenetics can be defined as 'the structural adaptation of chromosomal regions so as to register, signal, or perpetuate altered activity states.' Increased transcription of key regulatory, metabolic, and myogenic genes is an early response to exercise and is important in mediating subsequent adaptations in skeletal muscle. DNA hypomethylation and histone hyperacetylation are emerging as important crucial events for increased transcription. The complex interactions between multiple epigenetic modifications and their regulation by metabolic changes and signaling events during exercise, with implications for enhanced understanding of the acute and chronic adaptations to exercise, are questions for further investigation.

PMID:
31279665
DOI:
10.1016/j.tem.2019.06.002

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center