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Br J Anaesth. 2019 Jul 2. pii: S0007-0912(19)30442-8. doi: 10.1016/j.bja.2019.05.038. [Epub ahead of print]

Transient subcortical functional connectivity upon emergence from propofol sedation in human male volunteers: evidence for active emergence.

Author information

1
Division of Anaesthesia, Intensive Care and Pain Medicine, Tel Aviv Medical Center, Tel Aviv, Israel. Electronic address: Tommer.Nir@mountsinai.org.
2
Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
3
Division of Anaesthesia, Intensive Care and Pain Medicine, Tel Aviv Medical Center, Tel Aviv, Israel.
4
Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
5
Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
6
Division of Anaesthesia, Intensive Care and Pain Medicine, Tel Aviv Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Abstract

BACKGROUND:

Emergence from sedation entails rapid increase in the levels of both awareness and wakefulness, the two axes of consciousness. Functional MRI (fMRI) studies of emergence from sedation often focus on the recovery period, with no description of the moment of emergence. We hypothesised that by focusing on the moment of emergence, novel insights, primarily about subcortical activity and increased wakefulness, will be gained.

METHODS:

We conducted a resting state fMRI analysis of 17 male subjects (20-40 yr old) gradually entering into and emerging from deep sedation (average computed propofol concentrations of 2.41 and 1.11 μg ml-1, respectively), using target-controlled infusion of propofol.

RESULTS:

Functional connectivity analysis revealed a robust spatiotemporal signature of return of consciousness, in which subcortical seeds showed transient positive correlations that rapidly turned negative shortly after emergence. Elements of this signature included four components of the ascending reticular activating system: the ventral tegmentum area, the locus coeruleus, median raphe, and the mammillary body. The involvement of the rostral dorsolateral pontine tegmentum, which is specifically impaired in comatose patients with pontine lesions, in emergence was previously unknown.

CONCLUSIONS:

Emergence from propofol sedation is characterised, and possibly driven, by a transient activation of brainstem loci. Some of these loci are known components of the ascending reticular activating system, whereas an additional locus was found that is also impaired in comatose patients.

KEYWORDS:

MRI; ascending reticular activating system; brainstem; coma; consciousness; emergence; propofol; sedation

PMID:
31277837
DOI:
10.1016/j.bja.2019.05.038

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