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Psychoneuroendocrinology. 2019 Oct;108:135-139. doi: 10.1016/j.psyneuen.2019.06.014. Epub 2019 Jun 26.

Changes in cytokines during treatment of elderly, hospitalized psychiatric patients - a naturalistic study.

Author information

1
University Hospital of North Norway, Division of Mental Health and Substance Use, 9037, Tromsø, Norway; UiT, The Arctic University of Norway, Department of Clinical Medicine, 9038 Tromsø, Norway. Electronic address: erlend.bugge@unn.no.
2
University Hospital of North Norway, Division of Mental Health and Substance Use, 9037, Tromsø, Norway; UiT, The Arctic University of Norway, Department of Clinical Medicine, 9038 Tromsø, Norway.
3
Research Laboratory, Nordland Hospital, Bodø, and UiT, The Arctic University of Norway, K.G. Jebsen TREC, 9038 Tromsø, Norway; Department of Immunology, Oslo University Hospital and University of Oslo, 0372 Oslo, Norway; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
4
Norwegian University of Science and Technology, Faculty of Medicine and Health Sciences, Institute of Mental Health, 7491 Trondheim, Norway.
5
Mayo Clinic, Department of Psychiatry and Psychology, 200 First St SW, Rochester, MN 55905, USA.

Abstract

Immunological abnormalities have been demonstrated in several psychiatric disorders. Predominantly, studies have focused on younger adults, and research on elderly psychiatric in-patients is scant. In this naturalistic study, we investigated changes in cytokine levels during the treatment of diagnostically unselected elderly psychiatric in-patients, and whether these changes could be related to clinical outcomes. Clinical variables, demographic data, lifestyle data, and blood samples, including 27 plasma cytokines representing a broad spectrum of inflammatory mediators, were collected from 81 patients, 60 years and older, at admission and discharge. A subgroup of 49 patients also completed a self-reported clinical, psychiatric status form, indicating their level of recovery during hospitalisation. Statistical analyses demonstrated that a broad range of cytokines fell during treatment, and the fall was associated with clinical improvement, irrespective of psychiatric and somatic diagnoses. Exploiting cytokines as biomarkers of clinical traits might to be of limited use in a general population of elderly psychiatric in-patients as the field stands now.

KEYWORDS:

Cytokine; Depression; Gerontopsychiatric; Neuroimmunology; Neuroinflammation; Psychogeriatric

PMID:
31276906
DOI:
10.1016/j.psyneuen.2019.06.014
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