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BMJ Open Ophthalmol. 2019 Jun 4;4(1):e000248. doi: 10.1136/bmjophth-2018-000248. eCollection 2019.

Metagenomics in ophthalmology: current findings and future prospectives.

Author information

1
St Paul's Eye Unit, Department of Corneal and External Eye Diseases, Royal Liverpool University Hospital, Liverpool, United Kingdom.
2
Department of Doctoral Studies, Riga Stradins University, Riga, Latvia.
3
Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom.
4
Fondazione Banca Degli Occhi Del Veneto Onlus, Zelarino, Venezia, Italy.
5
Dipartimento di Specialità Medico-Chirurgiche, Scienze Radiologiche e Sanita Pubblica, Universita degli Studi di Brescia, Brescia, Italy.
6
Centre for Integrative Biology (CIBIO), Trento University, Trento, Italy.

Abstract

Less than 1% of all microorganisms of the available environmental microbiota can be cultured with the currently available techniques. Metagenomics is a new methodology of high-throughput DNA sequencing, able to provide taxonomic and functional profiles of microbial communities without the necessity to culture microbes in the laboratory. Metagenomics opens to a 'hypothesis-free' approach, giving important details for future research and treatment of ocular diseases in ophthalmology, such as ocular infection and ocular surface diseases.

KEYWORDS:

cornea; eye; metagenomics; microbiome; ocular surface; ophthalmology; sequencing

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