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Evid Based Complement Alternat Med. 2019 Jun 3;2019:2709486. doi: 10.1155/2019/2709486. eCollection 2019.

Applying Pulse Spectrum Analysis to Facilitate the Diagnosis of Coronary Artery Disease.

Huang YC1,2, Chang YH3, Cheng SM4, Lin SJ1,2,5,6, Lin CJ2, Su YC1,6,7.

Author information

1
Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
2
Department of Chinese Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
3
ChanDer Clinic, Taichung 40356, Taiwan.
4
Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
5
ChanDer Clinic, Taipei 10646, Taiwan.
6
School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
7
National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11221, Taiwan.

Abstract

Not all patients with angina pectoris have coronary artery stenosis. To facilitate the diagnosis of coronary artery disease (CAD), we sought to identify predictive factors of pulse spectrum analysis, which was developed by Wang and is one technique of modern pulse diagnosis. The patients suffered from chest pain and received cardiac catheterization to confirm the CAD diagnosis and Gensini score were recruited. Their pulse waves of radial artery were recorded. Then, by performing a fast Fourier transform, 10 amplitude values of frequency spectrum harmonics were obtained. Each harmonic amplitude was divided by the sum of all harmonic amplitude values, obtaining the relative percentages of 10 harmonics (C1-C10). Subsequently, multivariate logistic regression was conducted with two models and the areas under the receiver operating characteristic curves (ROC) of these 2 models were compared to see if combining the pulse diagnosis parameters with the risk factor of CAD can increase the prediction rate of CAD diagnosis. The predictive factors of CAD severity were analyzed by multivariate linear regression. A total of 83 participants were included; 63 were diagnosed CAD and 20 without CAD. In the CAD group, C1 was greater and C5 was lower than those of the non-CAD group. The CAD risk factors were put alone in Model 1 to perform the multivariate logistic regression analysis which had a prediction rate of 77.1%; while putting the C1 and C5 harmonics together with the risk factors into Model 2, the prediction rate increased to 80.7%. Finally, the area under ROC of Model 1 and Model 2 was 0.788 and 0.856, respectively. Furthermore, left C1, left C5, gender, and presence of hyperlipidemia were predictors of CAD severity. Therefore, pulse spectrum analysis may be a tool to facilitate CAD diagnosis before receiving cardiac catheterization. The harmonics C1 and C5 were favorable predictive indicators.

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