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Front Neural Circuits. 2019 Jun 18;13:42. doi: 10.3389/fncir.2019.00042. eCollection 2019.

Abnormal Interactions of the Salience Network, Central Executive Network, and Default-Mode Network in Patients With Different Cognitive Impairment Loads Caused by Leukoaraiosis.

Chen H1, Li Y2,3,4,5,6, Liu Q7, Shi Q2,3,4,5,6,7,8, Wang J2,3,4,5,6,7,9, Shen H1, Chen X1, Ma J1, Ai L10, Zhang YM2,3,4,5,6,7.

Author information

1
Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
2
Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
3
Center of Stroke, National Clinical Research Center for Neurological Diseases, Beijing, China.
4
Beijing Institute for Brain Disorders, Beijing, China.
5
Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
6
Beijing Key Laboratory of Central Nervous System Injury, Beijing, China.
7
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
8
Department of Neurology, Beijing Pinggu Hospital, Beijing, China.
9
Department of Neurology, General Hospital of The Yang Tze River Shipping, Wuhan Brain Hospital, Wuhan, China.
10
Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Abstract

Leukoaraiosis (LA) is associated with cognitive impairment in the older people which can be demonstrated in functional connectivity (FC) based on resting-state functional magnetic resonance imaging (rs-fMRI). This study is to explore the FC changes in LA patients with different cognitive status by three network models. Fifty-three patients with LA were divided into three groups: the normal cognition (LA-NC; n = 14, six males), mild cognitive impairment (LA-MCI; n = 27, 13 males), and vascular dementia (LA-VD; n = 12, six males), according to the Mini Mental State Exam (MMSE) and Clinical Dementia Rating (CDR). The three groups and 30 matched healthy controls (HCs; 11 males) underwent rs-fMRI. The data of rs-fMRI were analyzed by independent components analysis (ICA) and region of interest (ROI) analysis by the REST toolbox. Then the FC was respectively analyzed by the default-mode network (DMN), salience networks (SNs) and the central executive network (CEN) with their results compared among the different groups. For inter-brain network analysis, there were negative FC between the SN and DMN in LA groups, and the FC decreased when compared with HC group. While there were enhanced inter-brain network FC between the SN and CEN as well as within the SN. The FC in patients with LA can be detected by different network models of rs-fMRI. The multi-model analysis is helpful for the further understanding of the cognitive changes in those patients.

KEYWORDS:

central executive network; default-mode network; functional connectivity; leukoaraiosis; resting-state MRI; salience network

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