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Saudi J Gastroenterol. 2019 May 9. doi: 10.4103/sjg.SJG_56_19. [Epub ahead of print]

Development of pancreatic cancer during observation for hepatocellular carcinoma: A retrospective cohort study.

Author information

1
Department of Radiology, Graduate School of Medicine, The University of Tokyo, Japan.
2
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.
3
Department of Radiology, The University of Tokyo Hospital, Japan.
4
Section of Radiation Biology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Japan.

Abstract

Background/Aims:

We aimed to investigate incidence, characteristics, and possible risk factors of pancreatic cancer in patients under observation for hepatocellular carcinoma (HCC) because the association of hepatitis virus B infection and pancreatic cancer has been reported.

Patients and Methods:

We performed a retrospective cohort study in the Gastroenterology Department of a University Hospital in Japan between 2004 and 2012. A total of 1848 patients who underwent treatment for HCC were included at the initiation of treatment for HCC (mean follow-up period, 33.6 months). The patients received trimonthly radiological follow-ups. Newly developed cases of pancreatic cancer during follow-up for HCC were compared with that of an age- and sex-matched theoretical cohort from national statistics. Possible predisposing factors for pancreatic cancer related to HCC were assessed. Cumulative probabilities of developing a pancreatic cancer were compared using log-rank test.

Results:

About 13 of 1848 patients developed pancreatic cancer (mean follow-up period, 45.2 months). The risk ratio for all patients was 3.02 (log-rank test: P =0.01). Statistical analyses showed no effects of the following factors on the development of pancreatic cancer: age, sex, follow-up period, alcohol intake, laboratory data, presence of hepatitis virus, characteristics of HCC, type of treatment, number of radiological examinations, and cumulative effective dose.

Conclusions:

Increased incidence of pancreatic cancer was found in patients under observation for HCC in a relatively small cohort. HCC or other common underlying conditions might be a risk factor for development of pancreatic cancer.

KEYWORDS:

Hepatitis virus; liver cirrhosis; metachronous cancer; pancreas; radiation-induced cancer; synchronous cancer

PMID:
31274472
DOI:
10.4103/sjg.SJG_56_19
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