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Med Sci (Paris). 2019 Jun-Jul;35(6-7):549-555. doi: 10.1051/medsci/2019096. Epub 2019 Jul 5.

[From human pluripotent stem cells to custom-made intestinal organoids].

[Article in French]

Author information

1
UMR Inserm 1235, TENS (neuropathies du système nerveux entérique et pathologies digestives), Inserm, Université de Nantes, Institut des Maladies de l'Appareil Digestif, CHU de Nantes, 1, rue Gaston Veil, 44035 Nantes Cedex 1, France - Service de pédiatrie générale et génétique médicale, CHRU de Brest, Brest, France.
2
UMR Inserm 1235, TENS (neuropathies du système nerveux entérique et pathologies digestives), Inserm, Université de Nantes, Institut des Maladies de l'Appareil Digestif, CHU de Nantes, 1, rue Gaston Veil, 44035 Nantes Cedex 1, France.
3
UMR Inserm 1235, TENS (neuropathies du système nerveux entérique et pathologies digestives), Inserm, Université de Nantes, Institut des Maladies de l'Appareil Digestif, CHU de Nantes, 1, rue Gaston Veil, 44035 Nantes Cedex 1, France - Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 États-Unis.

Abstract

The study of gut diseases is often limited by the access to human biological tissues and animal models that do not faithfully mimic the human pathologies. In this context, the development of intestinal organoids from human pluripotent stem cells is paving the way of gastrointestinal physiology and digestive disease study. In this review, we recall the embryonic development of the digestive tract and its translation to human pluripotent stem cell differentiation. We also present the different types of intestinal organoids that can be generated, as well as their applications in research.

PMID:
31274085
DOI:
10.1051/medsci/2019096

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