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Med Sci (Paris). 2019 Jun-Jul;35(6-7):535-543. doi: 10.1051/medsci/2019093. Epub 2019 Jul 5.

[Microsatellite instability and cancer: from genomic instability to personalized medicine].

[Article in French]

Author information

1
Sorbonne Université, UPMC Univ Paris 06, Inserm, UMRS 938, Équipe Instabilité des microsatellites et cancer, Centre de recherche Saint Antoine, 75012 Paris, France Équipe labellisée par la Ligue nationale ontre le cancer et SIRIC CURAMUS, APHP.6.
2
Sorbonne Université, UPMC Univ Paris 06, Inserm, UMRS 938, Équipe Instabilité des microsatellites et cancer, Centre de recherche Saint Antoine, 75012 Paris, France Équipe labellisée par la Ligue nationale ontre le cancer et SIRIC CURAMUS, APHP.6 - Sorbonne Université, Department of Digestive Surgery, AP-HP, Hôpital Saint-Antoine, F-75012, Paris, France.
3
Sorbonne Université, UPMC Univ Paris 06, Inserm, UMRS 938, Équipe Instabilité des microsatellites et cancer, Centre de recherche Saint Antoine, 75012 Paris, France Équipe labellisée par la Ligue nationale ontre le cancer et SIRIC CURAMUS, APHP.6 - AP-HP, Service d'anatomie et cytologie pathologiques, 75012 Paris, France.
4
Département d'hépatogastroentérologie, Hôpital universitaire de Poitiers, 86021 Poitiers, France.
5
Département de gastroentérologie et oncologie digestive, Hôpital Européen George Pompidou, APHP, 75015 Paris, France.

Abstract

The human tumor phenotype referred to as MSI (Microsatellite Instability) is associated with inactivating alterations in MMR genes (Mismatch Repair). MSI was first observed in inherited malignancies associated with Lynch syndrome and later in sporadic colon, gastric and endometrial cancers. MSI tumors develop through a distinctive molecular pathway characterized by genetic instability in numerous microsatellite DNA repeat sequences throughout the genome. In this article, french researchers and physicians who have been recently awarded by the Fondation de France (Jean and Madeleine Schaeverbeke prize) make a sum of their activity in the MSI cancer field for more than 20 years. Their findings have greatly contributed to increase our knowledge of this original cancer model, laying the foundation for a personalized medicine of MSI tumors.

PMID:
31274083
DOI:
10.1051/medsci/2019093

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